Lab Overview We seek to leverage modern genomic and genome-scale functional genetic technologies to dissect the molecular underpinnings and vulnerabilities of cancer. We have an interest in deep mechanistic study of the pathways that underlie cancer initiation, progression, and drug resistance in genitourinary cancers (especially cancers of the prostate and kidney).
Mission Our overarching mission is to make scientific discoveries that accelerate the development of life-extending treatments for patients with cancer, with a focus on those with genitourinary cancers. We aim to elucidate the drivers and vulnerabilities of genitourinary cancers by integrating genomic profiling of primary tissue specimens with functional approaches in in vitro and in vivo systems. We are a highly collaborative research group engaged in joint projects with scientists and clinicians of diverse expertise. In addition to basic and translational research output, we are also deeply committed to mentoring the next generation of physicians and scientists.
Join our Team! Positions available for graduate students (BBS Program) and postdoctoral fellows to join our team. Please click here if you are interested in joining the the lab!
Lab News
November 2022
• Our paper on XIST activation in male cancers is out in Cell Systems LINK
September 2022
• Thank you to the Kidney Cancer Association for supporting our lab with a KCA Trailblazer Award!
August 2022
• eLife Insight article on androgen receptor splicing LINK
• Our work prostate cancer whole genome analysis now published in JCI Insight LINK
• Thank you to the V Foundation for supporting our lab with a V Scholar Award!
February 2022
• Our work identifying PRMT1 as a vulnerability in prostate cancer is now published in Cell Reports: LINK
January 2022
• Our work on the genomic landscape of tRCC is now published in Cell Reports: LINK
• New preprint on the landscape of structural variation in prostate cancer.
LINK
• Thank you to the Damon Runyon Cancer Research Foundation for supporting our lab's work with a Damon Runyon-Rachleff Innovation Award!
LINK
December 2021
• Congratulations to Shatha on winning a People’s Choice Award for her poster at the 17th Annual Broad Retreat!
• Congratulations to Jiao on being awarded a postdoctoral fellowship from the DoD Kidney Cancer Research Program! LINK
September 2021
• Congratulations to Jiao on a fellowship from the National Cancer Center. LINK
April 2021
• New preprint on the genomic landscape of translocation renal cell carcinoma now on bioRxiv
LINK
March 2021
• Congratulations to Shatha on being awarded a postdoctoral fellowship from the DoD Kidney Cancer Research Program! LINK.
July 2020
• Welcome Vidya; goodbye and good luck to Stephen!
June 2020
• First preprint from the lab is up on BioRxiv. LINK.
June 2020
• We're back (at least partially)!
April 2020
• Shutting down the lab for the COVID pandemic...stay safe everyone!
September 2019
• We welcome the first members of the lab: Emma, Nebiyou, and Stephen!
August 2019
• Hello World! The Viswanathan Lab is official!